https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48712 Wed 29 Mar 2023 17:13:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46554 Wed 29 Mar 2023 11:55:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50429 Wed 28 Aug 2024 15:43:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45095 n = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. Effects on cognition, cerebral blood flow, cerebrovascular responsiveness (CVR) and cardiometabolic markers (blood pressure, diabetes markers and fasting lipids) were assessed. Compared to placebo, resveratrol improved overall cognitive performance (P < 0.001) and attenuated the decline in CVR to cognitive stimuli (P = 0.038). The latter effect was associated with reduction of fasting blood glucose (r = −0.339, P = 0.023). This long-term study confirms that regular consumption of resveratrol can enhance cognitive and cerebrovascular functions in postmenopausal women, with the potential to slow cognitive decline due to ageing and menopause.]]> Wed 26 Oct 2022 12:53:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30472 Wed 11 Apr 2018 12:58:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28572 Wed 11 Apr 2018 09:20:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33113 Wed 04 Sep 2019 09:56:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41409 Wed 03 Aug 2022 11:24:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52900 Tue 31 Oct 2023 15:46:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52536 Tue 17 Oct 2023 10:05:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45541 2) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil. Conclusion: Regular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention. Clinical trial registration: ACTRN12616000732482p.]]> Tue 14 Nov 2023 14:41:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33423 Tue 03 Sep 2019 18:01:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25049 Thu 28 Oct 2021 13:05:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41204 Thu 28 Jul 2022 11:26:39 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15586 Sat 24 Mar 2018 08:25:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28570 trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.]]> Sat 24 Mar 2018 07:35:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32870 Mon 23 Sep 2019 14:04:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49575 Mon 22 May 2023 10:37:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49574 Mon 22 May 2023 10:30:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49555 Mon 22 May 2023 09:13:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35057 Mon 17 Jun 2019 10:29:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46183 Mon 14 Nov 2022 10:13:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38520 Mon 09 May 2022 16:19:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35486 Fri 16 Aug 2019 13:43:22 AEST ]]>